Woody Allen plays Tex, a kosher butcher. Sharon Stone plays his unfaithful wife Candy. Tex catches Candy in the act and in a fit of rage he kills her. To conceal his crime he cuts up her body and buries it in the desert in New Mexico. However, when her hand surfaces, a blind woman trips over it and it restores her sight. The hand is then considered to be the "hand of the Virgin." Despite the church's fallen priest objecting, the ambitious mayor of the town creates an international three-ring circus of miracle-seekers, TV crews, and born-again local prostitutes all interested in the hand. All of this goes on while Tex is desperately trying to recover the hand before the sheriff finds it and uses it as evidence against him.

A company that produces a toxic chemical tries to improve its image via a popular spokesperson, Ricky Coogan. Ricky travels to South America to get a first-hand look at the chemical's effects and finds himself at a mutant freak farm. Elijah, who runs the farm, is only too happy to have new subjects on which to try his freak machine. The very chemical that Ricky is supposed to promote is the one responsible for creating the great variety of freaks.

One day California wakes up and not a single Latino is left in the state. They have all inexplicably dissappeared, chaos, tragedy, and comedy quickly ensue.